منابع مشابه
Autism: A “Critical Period” Disorder?
Cortical circuits in the brain are refined by experience during critical periods early in postnatal life. Critical periods are regulated by the balance of excitatory and inhibitory (E/I) neurotransmission in the brain during development. There is now increasing evidence of E/I imbalance in autism, a complex genetic neurodevelopmental disorder diagnosed by abnormal socialization, impaired commun...
متن کاملpostural control impairments in individuals with autism spectrum disorder: a critical review of current literature
conclusions examining postural control as an endophenotype or early diagnostic marker of autism is a conceptual premise which should be considered in future investigations. at the end of the review, methodological recommendations on the assessment of postural control have also been provided. results individuals with asd have problems in maintaining postural control in infancy that well persists...
متن کاملAutism Spectrum Disorder - A Complex Genetic Disorder.
Autism spectrum disorder is an entity that reflects a scientific consensus that several previously separated disorders are actually a single spectrum disorder with different levels of symptom severity in two core domains - deficits in social communication and interaction, and restricted repetitive behaviors. Autism spectrum disorder is diagnosed in all racial, ethnic and socioeconomic groups an...
متن کاملAutism as the Early Closure of a Neuroplastic Critical Period Normally Seen in Adolescence.
The most severe cases of autism are diagnosed by extreme social dysfunction and other behavioral abnormalities. A number of genetic studies have been conducted to correlate behavioral phenotypes to genetic dysfunctions, but no "autism gene" has yet been discovered. In addition, environmental factors have been found to influence the development of autistic traits with high probability. This revi...
متن کاملCritical period plasticity and sensory function in a neuroligin-3 model of autism
Extensive experience-dependent refinement of cortical circuits is restricted to critical periods of plasticity early in life. The timing of these critical periods is tightly regulated by the relative levels of excitatory and inhibitory (E/I) neurotransmission during development. Genetic disruption of synaptic proteins that normally maintain E/I balance can result in severe behavioral dysfunctio...
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ژورنال
عنوان ژورنال: Neural Plasticity
سال: 2011
ISSN: 2090-5904,1687-5443
DOI: 10.1155/2011/921680